Negative regulation of osteoblast proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of osteoblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLE4, PSMD2, and SPACA6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLE4 grouped by Negative regulation of osteoblast proliferation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	POLE4 →	+1.775	+1.841	.003	<.001	3	3
SOFT_TISSUE	PSMD2 →	+1.283	+1.421	.008	.005	3	3
BONE	SPACA6 →	+0.902	+1.702	.003	<.001	3	3
LUNG_NSCLC_LUSC	ZNF516 →	-1.462	-1.105	.001	.003	3	3
LUNG_NSCLC_LUSC	NDUFB5 →	-1.410	-1.523	.002	.004	3	3
LUNG_NSCLC_LUSC	COA5 →	-0.916	-1.619	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLE4 by Negative regulation of osteoblast proliferation activity — BONE

Explore this box plot interactively →