Negative regulation of osteoblast proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of osteoblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRIN2D, ETFBKMT, and TMEM50A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of osteoblast proliferation activity versus GRIN2D in URINARY_TRACT (Pearson r = 0.98).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GRIN2D →	+2.903	+1.543	<.001	<.001	3	3
LUNG_NSCLC_LUAD	ETFBKMT →	+0.478	+1.401	<.001	.005	3	3
BREAST	TMEM50A →	+0.853	+1.676	.007	<.001	3	3
SKIN	GPC3 →	-1.958	-1.257	.006	.007	3	2
SKIN	HENMT1 →	+3.157	+1.589	<.001	<.001	3	2
SKIN	SEMA3E →	-3.110	-1.351	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033689 vs GRIN2D — URINARY_TRACT

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