Negative regulation of viral transcription

Across TCGA cell cohorts, RNA activity of the Negative regulation of viral transcription pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP4, UGT8, and LCA5L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of viral transcription activity versus LRP4 in CNS (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LRP4 →	-1.917	-1.210	.003	<.001	3	5
LUNG_SCLC	UGT8 →	+2.109	+1.202	.002	<.001	3	4
BREAST	LCA5L →	-0.534	-0.547	.003	.002	3	4
URINARY_TRACT	GLIPR1 →	+3.393	+1.310	<.001	.001	3	4
KIDNEY	TMSB15B →	+0.786	+1.007	.009	.004	3	4
BLOOD_Myeloma	ABRACL →	+0.857	+1.085	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032897 vs LRP4 — CNS

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