Negative regulation of viral transcription

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of viral transcription pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 15 member genes.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher Negative regulation of viral transcription pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and GBM, show the opposite pattern, with higher activity associated with better survival.

LUAD, ACC, and READ are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.448	0.293	<.001	52	view →
ACC	DFS	Quartile	II,III,IV	0.204	0.693	<.001	46	view →
READ	DFS	Tertile	IV	0.322	0.832	.010	28	view →
KIRC	DFS	Median	II,III,IV	0.440	0.630	.009	26	view →
ESCA	OS	Median	IV	0.135	0.568	.031	24	view →
UCEC	DFS	Quartile	All	0.502	0.765	.002	24	view →
GBM	DFS	Tertile	All	0.480	0.196	.005	15	view →
OV	OS	Tertile	III,IV	0.305	0.398	.023	12	view →
BRCA	DFS	Quartile	IV	0.856	0.337	.024	12	view →
LIHC	DFS	Tertile	All	0.407	0.592	.002	11	view →
KIRP	OS	Median	All	0.534	0.772	.004	10	view →
THYM	OS	Median	All	1.000	0.765	.005	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0032897–LUAD (OS)

Open the LUAD breakdown →