Q-omics provides the consensus-scored TMSB15B profile across patient tissues and cancer cell-line models. TMSB15B expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, TMSB15B is differentially expressed in 13, with the highest sampling consensus in KIRP. Additionally, TMSB15B RNA expression shows 19,167 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight UCEC, and KIRP as cancer lineages where TMSB15B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TMSB15B — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TMSB15B survival associations across molecular data types. TMSB15B RNA expression shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TMSB15B RNA expression–survival associations across cancer types. High TMSB15B expression shows unfavorable associations in UCEC, KIRP, ACC, LUSC, PCPG and HNSC. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UCEC as the clearest survival context for TMSB15B RNA expression.
This table summarizes TMSB15B tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for TMSB15B. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TMSB15B shows lower tumor expression in KICH and higher tumor expression in KIRP, KIRC, HNSC, STAD and LUSC. The KIRP box plot shows higher TMSB15B RNA expression in tumor versus normal tissue (log2 FC = +0.308, t-test p < 0.001).
This table shows molecular features associated with TMSB15B in patient tissues and cancer cell lines. In patient samples, TMSB15B shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set. In cancer cell lines, TMSB15B RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in LUNG_SCLC and BLOOD_Leukemia.
