TMSB15B

Across TCGA pan-cancer cohorts, TMSB15B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TMSB15B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where TMSB15B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMSB15B is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

KIRP, KIRC, and HNSC are the cancer types where TMSB15B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMSB15B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.308	<.001	11	view →
KIRC	Female	All	+0.150	<.001	11	view →
HNSC	Male	III,IV	+0.196	<.001	10	view →
KICH	Female	All	−0.100	<.001	7	view →
STAD	All	III,IV	+0.100	.001	7	view →
LUSC	All	All	+0.222	<.001	6	view →
BRCA	All	II,III,IV	+0.099	.002	4	view →
CHOL	Female	All	+0.230	<.001	3	view →
ESCA	All	All	+0.173	<.001	3	view →
LIHC	All	All	+0.018	.006	3	view →
BLCA	All	All	+0.235	.028	2	view →
LUAD	All	All	+0.072	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TMSB15B–KIRP

Open the KIRP breakdown →