TMSB15B

Across TCGA pan-cancer cohorts, TMSB15B RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TMSB15B data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TMSB15B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TMSB15B expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

UCEC, KIRP, and ACC are the cancer types where TMSB15B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.632	0.845	<.001	92	view →
KIRP	OS	Tertile	All	0.870	0.989	<.001	78	view →
ACC	OS	Quartile	All	0.378	0.874	<.001	75	view →
LUSC	DFS	Tertile	III,IV	0.243	0.644	<.001	38	view →
PCPG	OS	Median	All	0.632	1.000	.009	27	view →
HNSC	DFS	Median	All	0.432	0.637	.004	23	view →
KIRC	DFS	Tertile	All	0.791	0.505	.002	20	view →
LGG	DFS	Tertile	All	0.811	0.638	.003	18	view →
SKCM	OS	Median	All	0.374	0.253	.004	18	view →
ESCA	OS	Quartile	All	0.334	0.599	.014	18	view →
STAD	DFS	Tertile	All	0.601	0.817	.016	15	view →
CHOL	DFS	Median	II,III,IV	0.555	0.112	.008	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TMSB15B–UCEC (OS)

Open the UCEC breakdown →