Detection of lipopolysaccharide

Across TCGA patient cohorts, RNA activity of the Detection of lipopolysaccharide pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIPF1, LMNA_S423, and STAB1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of lipopolysaccharide activity versus WIPF1 in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WIPF1 →	+0.449	+0.074	<.001	<.001	3	8
BRCA	LMNA_S423 →	+1.272	+0.081	<.001	<.001	3	8
GBM	STAB1 →	+0.477	+0.122	<.001	<.001	3	8
LSCC	PLEKHO2_T311 →	+0.440	+0.080	<.001	<.001	3	8
GBM	SYNPO2_S930 →	+1.327	+0.163	<.001	<.001	3	7
LSCC	TLN1_S1201 →	+0.729	+0.087	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032497 vs WIPF1 — OV

Explore this scatter interactively →