Detection of lipopolysaccharide

Across TCGA cell cohorts, RNA activity of the Detection of lipopolysaccharide pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF175, ZMAT2, and B3GNT9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF175 grouped by Detection of lipopolysaccharide-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RNF175 →	+0.813	+1.010	.008	.005	3	3
OVARY	ZMAT2 →	+0.355	+0.976	.006	.001	3	3
OVARY	B3GNT9 →	+1.029	+1.171	.004	<.001	2	4
BLOOD_Lymphoma	CTDSPL2 →	+1.195	+1.861	.002	.006	3	3
BLOOD_Lymphoma	SIN3A →	+1.120	+1.861	.001	.006	3	3
SKIN	SALL2 →	+0.983	+0.797	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF175 by Detection of lipopolysaccharide activity — OVARY

Explore this box plot interactively →