Negative regulation of chondrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of chondrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM7, GGCT, and SMPD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chondrocyte differentiation activity versus MCM7 in PANCREAS (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MCM7 →	+1.145	+1.478	.001	<.001	3	5
PANCREAS	GGCT →	+0.936	+1.260	.009	.009	3	5
STOMACH	SMPD1 →	-2.188	-1.815	.001	<.001	3	5
BONE	SHOX2 →	-2.456	-2.095	.008	<.001	3	5
KIDNEY	GPR1 →	-2.372	-1.373	.002	.007	3	4
STOMACH	EHD2 →	-3.008	-1.198	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032331 vs MCM7 — PANCREAS

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