Activation of protein kinase B activity

Across TCGA patient cohorts, RNA activity of the Activation of protein kinase B activity pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PHIP_S911, SMCHD1, and TOP2A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation of protein kinase B activity activity versus PHIP_S911 in LUAD (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PHIP_S911 →	-0.595	-0.049	<.001	.001	3	7
UCEC	SMCHD1 →	-0.289	-0.052	.001	.001	3	6
GBM	TOP2A →	-0.657	-0.062	<.001	<.001	3	6
UCEC	UTP25 →	-0.351	-0.045	.002	.008	3	6
BRCA	AHCTF1 →	-0.209	-0.026	<.001	<.001	3	6
BRCA	RIN2_S486 →	+0.540	+0.035	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032148 vs PHIP_S911 — LUAD

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