Activation of protein kinase B activity

Across TCGA pan-cancer cohorts, RNA activity of the Activation of protein kinase B activity pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 25 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Activation of protein kinase B activity pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and SKCM, show the opposite pattern, with higher activity associated with better survival.

UVM, KIRC, and THCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	1.000	0.434	<.001	99	view →
KIRC	DFS	Quartile	IV	0.149	0.448	.001	60	view →
THCA	DFS	Quartile	All	0.858	0.962	<.001	54	view →
LIHC	OS	Median	All	0.413	0.592	<.001	48	view →
SKCM	OS	Median	All	0.400	0.280	.001	39	view →
ACC	DFS	Tertile	All	0.505	0.785	.006	18	view →
BLCA	OS	Median	III,IV	0.447	0.669	.013	17	view →
LAML	DFS	Quartile	All	0.438	0.730	.034	16	view →
LUSC	DFS	Median	All	0.796	0.698	.014	11	view →
PRAD	DFS	Quartile	All	0.815	0.934	.003	10	view →
COAD	OS	Median	II,III,IV	0.922	0.813	.026	8	view →
KICH	OS	Median	II,III,IV	0.629	0.950	.016	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0032148–UVM (OS)

Open the UVM breakdown →