Cellular response to nutrient

Across TCGA cell cohorts, RNA activity of the Cellular response to nutrient pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR18, ZFP14, and BHLHE41, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to nutrient activity versus WDR18 in STOMACH (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	WDR18 →	+1.154	+1.617	.004	<.001	3	5
BLOOD_Leukemia	ZFP14 →	+0.625	+0.426	.004	.007	2	5
LIVER	BHLHE41 →	-3.078	-1.277	<.001	.002	3	4
LUNG_SCLC	PSMB10 →	-0.828	-0.760	<.001	.001	3	4
BONE	TOX4 →	-0.621	-0.318	<.001	.003	2	5
LIVER	CCNG1 →	+1.137	+1.469	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031670 vs WDR18 — STOMACH

Explore this scatter interactively →