Regulation of vesicle fusion

Across TCGA patient cohorts, RNA activity of the Regulation of vesicle fusion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CARMIL2_S1381, TGFB1I1, and UTP15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vesicle fusion activity versus CARMIL2_S1381 in GBM (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CARMIL2_S1381 →	+1.055	+0.125	<.001	<.001	3	5
GBM	TGFB1I1 →	-0.444	-0.129	<.001	<.001	3	5
GBM	UTP15 →	-0.253	-0.124	<.001	<.001	3	5
HNSC	WDR74 →	-0.138	-0.036	.002	.007	3	5
LSCC	EVL_S246 →	+0.531	+0.042	<.001	<.001	3	5
UCEC	LSAMP →	+0.770	+0.049	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031338 vs CARMIL2_S1381 — GBM

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