Response to caffeine

Across TCGA patient cohorts, RNA activity of the Response to caffeine pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, MSH6, and LIN54_S635, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to caffeine activity versus SMC2 in BRCA (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMC2 →	+0.609	+0.058	<.001	<.001	3	6
BRCA	MSH6 →	+0.521	+0.068	<.001	<.001	3	6
BRCA	LIN54_S635 →	+0.443	+0.040	.001	.009	3	6
BRCA	RFC5 →	+0.360	+0.059	<.001	<.001	3	6
BRCA	TOP2A_S1377 →	+0.871	+0.049	<.001	.002	3	6
BRCA	EMG1 →	+0.308	+0.038	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031000 vs SMC2 — BRCA

Explore this scatter interactively →