Response to caffeine

Across TCGA patient cohorts, RNA activity of the Response to caffeine pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS6KL1, NEU3, and UNC5A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to caffeine activity versus RPS6KL1 in GBM (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPS6KL1 →	+0.495	+0.138	.002	<.001	3	4
HNSC	NEU3 →	+0.508	+0.188	.002	.001	3	4
GBM	UNC5A →	+0.909	+0.140	<.001	.004	3	3
HNSC	USHBP1 →	+0.335	+0.191	.004	<.001	3	3
GBM	SMC6 →	+0.222	+0.133	.006	.006	3	3
GBM	C1QL3 →	+0.836	+0.116	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031000 vs RPS6KL1 — GBM

Explore this scatter interactively →