Response to caffeine

Across TCGA cell cohorts, RNA activity of the Response to caffeine pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPTA1, CBX8, and TMEM97, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPTA1 grouped by Response to caffeine-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SPTA1 →	+0.246	+0.242	.001	.002	3	4
SOFT_TISSUE	CBX8 →	-0.139	-0.224	.003	.001	3	4
BONE	TMEM97 →	+0.338	+0.267	.005	<.001	3	4
BONE	IL15RA →	+0.594	+0.351	.003	<.001	3	4
BONE	ARF4 →	-0.440	-0.280	.001	.001	3	4
LUNG_NSCLC_LUSC	POLG →	+0.461	+0.202	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPTA1 by Response to caffeine activity — SOFT_TISSUE

Explore this box plot interactively →