Skeletal muscle thin filament assembly

Across TCGA patient cohorts, RNA activity of the Skeletal muscle thin filament assembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KIAA1522, NES_S905, and LAMA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle thin filament assembly activity versus KIAA1522 in BRCA (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KIAA1522 →	-0.249	-0.077	.004	.002	3	5
HNSC	NES_S905 →	+0.915	+0.452	<.001	<.001	3	5
HNSC	LAMA2 →	+1.842	+0.870	<.001	<.001	3	4
BRCA	COASY →	-0.316	-0.069	.003	.001	3	4
BRCA	CLINT1 →	-0.225	-0.083	.002	.001	3	4
BRCA	PALM2AKAP2 →	+0.294	+0.054	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030240 vs KIAA1522 — BRCA

Explore this scatter interactively →