Skeletal muscle thin filament assembly

Across TCGA pan-cancer cohorts, RNA activity of the Skeletal muscle thin filament assembly pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Skeletal muscle thin filament assembly pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LIHC and PAAD, show the opposite pattern, with higher activity associated with better survival.

KIRP, READ, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.262	0.701	<.001	87	view →
READ	OS	Median	All	0.727	0.906	.001	67	view →
BRCA	OS	Tertile	All	0.942	0.971	<.001	64	view →
HNSC	OS	Median	All	0.690	0.843	<.001	60	view →
LIHC	OS	Median	All	0.601	0.433	<.001	52	view →
UCEC	DFS	Median	All	0.785	0.882	<.001	32	view →
PAAD	DFS	Quartile	All	0.474	0.155	<.001	21	view →
MESO	OS	Tertile	IV	0.281	0.743	.004	21	view →
PCPG	DFS	Median	All	0.934	0.611	.001	19	view →
UCS	DFS	Quartile	II,III,IV	0.602	0.161	.009	18	view →
SKCM	OS	Median	II,III,IV	0.669	0.792	.011	17	view →
LUSC	OS	Median	II,III,IV	0.787	0.676	.014	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0030240–KIRP (OS)

Open the KIRP breakdown →