Neural tube patterning

Across TCGA cell cohorts, RNA activity of the Neural tube patterning pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC9A7, MECR, and SRD5A3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural tube patterning activity versus SLC9A7 in CNS (Pearson r = -0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SLC9A7 →	-2.130	-1.895	.008	.006	3	3
LARGE_INTESTINE	MECR →	-0.492	-0.134	.005	.003	3	3
LARGE_INTESTINE	SRD5A3 →	-1.248	-0.126	.001	.007	3	3
LARGE_INTESTINE	GOLGA8R →	-0.808	-0.129	.008	.006	3	3
LUNG_NSCLC_LUAD	RPP38 →	-0.853	-1.213	<.001	.002	3	3
BLOOD_Leukemia	HCCS →	+0.853	+1.292	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021532 vs SLC9A7 — CNS

Explore this scatter interactively →