Iron-sulfur cluster assembly

Across TCGA patient cohorts, RNA activity of the Iron-sulfur cluster assembly pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADNP, CASKIN1_S1257, and RPRD1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Iron-sulfur cluster assembly activity versus ADNP in HNSC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ADNP →	+0.290	+0.063	.003	.001	3	6
LSCC	CASKIN1_S1257 →	+1.157	+0.046	.001	.005	3	6
LSCC	RPRD1B →	+0.290	+0.037	.003	<.001	3	6
LUAD	PARN →	+0.159	+0.041	<.001	<.001	3	6
BRCA	ZC3H14 →	+0.160	+0.030	.005	.004	2	6
LSCC	RFC4 →	+0.335	+0.030	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016226 vs ADNP — HNSC

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