Organic acid catabolic process

Across TCGA patient cohorts, RNA activity of the Organic acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHF5A, TAF5, and RACGAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organic acid catabolic process activity versus PHF5A in COAD (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PHF5A →	-0.402	-0.102	<.001	.008	3	5
BRCA	TAF5 →	-0.432	-0.176	<.001	.003	3	4
BRCA	RACGAP1 →	-0.711	-0.277	.001	<.001	3	4
BRCA	SORBS1 →	+0.909	+0.195	.009	.004	3	4
COAD	SMC4 →	-0.421	-0.168	<.001	<.001	3	4
COAD	CENPL →	-0.402	-0.137	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016054 vs PHF5A — COAD

Explore this scatter interactively →