Organic acid catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Organic acid catabolic process pathway differs between tumor and matched normal tissue in 10 of the 18 cancer types tested.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRP and THCA, show the opposite pattern, with lower activity in tumor tissue.

KIRP, THCA, and KIRC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRP	All	III,IV	−0.090	<.001	11	view →
THCA	All	All	−0.017	<.001	10	view →
KIRC	Male	All	−0.048	<.001	9	view →
KICH	Male	II,III,IV	−0.073	<.001	8	view →
LIHC	All	II,III,IV	−0.052	<.001	8	view →
BRCA	All	All	−0.033	<.001	6	view →
CHOL	Male	All	−0.166	<.001	5	view →
LUAD	Male	II,III,IV	−0.018	.003	5	view →
LUSC	Male	All	−0.017	<.001	4	view →
HNSC	All	All	−0.014	.004	4	view →

Pink = more active in tumor, green = less active in tumor. Showing the 10 strongest of 10 lineages.

GO:0016054–KIRP

Open the KIRP breakdown →