Organic acid catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Organic acid catabolic process pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 252 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Organic acid catabolic process pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and BRCA, show the opposite pattern, with higher activity associated with better survival.

KIRP, BRCA, and CHOL are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.873	0.355	.008	56	view →
BRCA	OS	Median	III,IV	0.651	0.458	.004	46	view →
CHOL	OS	Tertile	II,III,IV	0.088	0.845	<.001	40	view →
THYM	OS	Tertile	All	0.897	1.000	.005	36	view →
LIHC	OS	Median	All	0.847	0.720	<.001	35	view →
ACC	OS	Tertile	III,IV	0.735	0.403	.015	25	view →
UCEC	DFS	Median	All	0.799	0.869	.028	24	view →
GBM	OS	Quartile	All	0.274	0.457	.005	18	view →
LGG	DFS	Tertile	All	0.627	0.798	<.001	18	view →
SKCM	DFS	Quartile	IV	0.061	0.777	.010	15	view →
READ	DFS	Median	All	0.902	0.451	.002	13	view →
COAD	DFS	Quartile	III,IV	0.617	0.778	.019	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0016054–KIRP (OS)

Open the KIRP breakdown →