Inorganic anion transport

Across TCGA patient cohorts, RNA activity of the Inorganic anion transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNRPD2, CLP1, and PRPF40A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inorganic anion transport activity versus SNRPD2 in GBM (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNRPD2 →	-0.314	-0.045	<.001	<.001	3	6
LUAD	CLP1 →	-0.167	-0.025	<.001	.008	3	6
GBM	PRPF40A →	-0.337	-0.043	<.001	.001	3	6
GBM	SUPT16H →	-0.496	-0.044	<.001	<.001	3	6
GBM	TPR →	-0.195	-0.035	.003	.001	3	6
GBM	MLKL →	+0.610	+0.052	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015698 vs SNRPD2 — GBM

Explore this scatter interactively →