Inorganic anion transport

Across TCGA pan-cancer cohorts, RNA activity of the Inorganic anion transport pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 171 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Inorganic anion transport pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LGG and KIRP, show the opposite pattern, with higher activity associated with better survival.

MESO, THCA, and KICH are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.327	0.600	<.001	99	view →
THCA	OS	Median	IV	0.474	0.871	.008	38	view →
KICH	DFS	Median	All	0.576	0.961	.004	33	view →
OV	OS	Quartile	III,IV	0.253	0.384	.006	24	view →
STAD	DFS	Tertile	III,IV	0.259	0.592	.005	21	view →
LGG	OS	Quartile	All	0.743	0.402	.001	19	view →
KIRP	OS	Quartile	II,III,IV	0.910	0.590	.021	14	view →
THYM	DFS	Quartile	All	0.567	0.948	.021	12	view →
PAAD	OS	Median	All	0.221	0.454	.007	11	view →
SCLC	DFS	Median	II,III,IV	0.305	0.594	.004	11	view →
ACC	OS	Tertile	All	1.000	0.452	.016	10	view →
LIHC	DFS	Tertile	All	0.294	0.427	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0015698–MESO (OS)

Open the MESO breakdown →