Inorganic anion transport

Across TCGA pan-cancer cohorts, RNA activity of the Inorganic anion transport pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRP and KIRC, show the opposite pattern, with lower activity in tumor tissue.

BLCA, KIRP, and STAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
BLCA	All	IV	+0.049	<.001	12	view →
KIRP	Female	II,III,IV	−0.056	<.001	9	view →
STAD	All	II,III,IV	+0.045	<.001	9	view →
LIHC	Female	II,III,IV	+0.030	<.001	9	view →
KIRC	All	All	−0.011	.001	7	view →
UCEC	All	All	+0.036	<.001	6	view →
HNSC	Female	IV	+0.015	.016	5	view →
LUAD	Male	II,III,IV	−0.016	.008	4	view →
CHOL	All	All	+0.047	<.001	3	view →
LUSC	All	All	−0.014	.002	3	view →
LUAD	Female	II,III,IV	+0.019	.006	2	view →
COAD	Female	All	−0.010	.044	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 11 lineages.

GO:0015698–BLCA

Open the BLCA breakdown →