Inorganic anion transport

Across TCGA patient cohorts, RNA activity of the Inorganic anion transport pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC4A4, RNF141, and TAF4B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inorganic anion transport activity versus SLC4A4 in PDAC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SLC4A4 →	+1.218	+0.895	<.001	<.001	3	6
GBM	RNF141 →	+0.619	+0.306	<.001	<.001	3	4
LUAD	TAF4B →	-0.492	-0.580	.001	.005	3	4
LUAD	SETD3 →	+0.265	+0.406	<.001	.007	3	4
UCEC	KDM7A-DT →	+0.867	+0.996	<.001	<.001	3	4
PDAC	LDHAL6EP →	+1.008	+0.940	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015698 vs SLC4A4 — PDAC

Explore this scatter interactively →