Negative regulation of platelet-derived growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of platelet-derived growth factor receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC12A4, GIGYF2, and HAAO, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of platelet-derived growth factor receptor signaling pathway activity versus SLC12A4 in LUAD (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SLC12A4 →	-0.205	-0.047	.003	.003	3	5
OV	GIGYF2 →	-0.158	-0.061	.009	.003	3	5
BRCA	HAAO →	+0.485	+0.043	<.001	<.001	3	4
CCRCC	THSD1_S776 →	-0.933	-0.092	.001	.005	3	4
GBM	AFAP1L1 →	-0.617	-0.066	<.001	<.001	3	4
CCRCC	ERG →	-0.297	-0.060	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010642 vs SLC12A4 — LUAD

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