Positive regulation of nuclear cell cycle DNA replication

Across TCGA patient cohorts, RNA activity of the Positive regulation of nuclear cell cycle DNA replication pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SETDB1_S1066, SMC2, and SMC4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nuclear cell cycle DNA replication activity versus SETDB1_S1066 in UCEC (Pearson r = 0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SETDB1_S1066 →	+1.172	+0.129	<.001	<.001	3	10
GBM	SMC2 →	+0.595	+0.060	<.001	<.001	3	10
GBM	SMC4 →	+0.572	+0.061	<.001	<.001	3	10
LSCC	LIG1 →	+0.570	+0.090	<.001	<.001	3	10
LSCC	RFC2 →	+0.380	+0.076	<.001	<.001	3	9
LSCC	RFC4 →	+0.470	+0.078	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010571 vs SETDB1_S1066 — UCEC

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