Regulation of ketone biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of ketone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM7, LMNB1, and TSHZ3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ketone biosynthetic process activity versus MCM7 in GBM (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MCM7 →	-0.629	-0.206	.001	<.001	3	6
GBM	LMNB1 →	-0.832	-0.252	.003	.001	3	5
UCEC	TSHZ3 →	+0.889	+0.512	<.001	.001	3	5
UCEC	KIF2C →	-0.955	-0.389	<.001	.003	3	5
UCEC	RECQL4 →	-0.982	-0.434	.001	.003	3	5
GBM	PBK →	-1.163	-0.201	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010566 vs MCM7 — GBM

Explore this scatter interactively →