Regulation of ketone biosynthetic process

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of ketone biosynthetic process pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 21 member genes.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher Regulation of ketone biosynthetic process pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and CHOL, show the opposite pattern, with higher activity associated with better survival.

COAD, LIHC, and SARC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	All	0.415	0.777	<.001	69	view →
LIHC	OS	Median	All	0.314	0.609	.001	46	view →
SARC	OS	Tertile	All	0.387	0.603	<.001	30	view →
KIRC	DFS	Median	III,IV	0.563	0.690	.018	29	view →
ESCA	DFS	Tertile	II,III,IV	0.314	0.546	.008	24	view →
STAD	OS	Quartile	All	0.268	0.698	<.001	21	view →
READ	DFS	Median	II,III,IV	0.930	0.659	.004	17	view →
CHOL	DFS	Median	All	0.657	0.201	.001	16	view →
UCEC	DFS	Quartile	All	0.462	0.810	.006	8	view →
THYM	OS	Quartile	All	0.746	1.000	.016	7	view →
MESO	OS	Quartile	II,III,IV	0.734	0.326	.026	6	view →
CESC	OS	Tertile	All	0.918	0.852	.033	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0010566–COAD (OS)

Open the COAD breakdown →