Oligosaccharide catabolic process

Across TCGA patient cohorts, RNA activity of the Oligosaccharide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTBS, IDNK, and CTSO, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligosaccharide catabolic process activity versus CTBS in UVM (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	CTBS →	+0.978	+0.042	<.001	<.001	3	27
UVM	IDNK →	+0.841	+0.037	<.001	<.001	3	26
UVM	CTSO →	+1.611	+0.047	<.001	<.001	3	25
UVM	GOLGA1 →	+0.938	+0.037	<.001	<.001	3	25
ACC	NEU3 →	+1.053	+0.063	<.001	<.001	3	25
SCLC	MR1 →	+1.257	+0.125	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009313 vs CTBS — UVM

Explore this scatter interactively →