Oligosaccharide catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Oligosaccharide catabolic process pathway is associated with patient survival in 17 of 34 cancer lineages. Pathway activity is summarized from the expression of its 18 member genes.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher Oligosaccharide catabolic process pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and ACC, show the opposite pattern, with higher activity associated with better survival.

BRCA, UVM, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	All	0.963	0.922	<.001	106	view →
UVM	DFS	Median	II,III,IV	0.547	0.887	<.001	92	view →
ACC	OS	Tertile	All	0.937	0.635	.001	72	view →
KIRC	DFS	Median	All	0.696	0.569	<.001	38	view →
UCEC	OS	Tertile	All	0.856	0.506	.006	24	view →
MESO	OS	Tertile	IV	0.237	0.791	.007	12	view →
LIHC	OS	Median	III,IV	0.678	0.381	.007	12	view →
SARC	OS	Tertile	All	0.890	0.763	.009	11	view →
HNSC	DFS	Quartile	III,IV	0.556	0.682	.017	10	view →
CHOL	DFS	Quartile	All	1.000	0.176	.011	9	view →
STAD	DFS	Tertile	IV	0.318	0.689	.044	6	view →
LUAD	DFS	Quartile	IV	0.882	0.429	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

GO:0009313–BRCA (DFS)

Open the BRCA breakdown →