Oligosaccharide catabolic process

Across TCGA patient cohorts, RNA activity of the Oligosaccharide catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TPP1, MPI, and PCNA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligosaccharide catabolic process activity versus TPP1 in OV (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TPP1 →	+0.402	+0.049	<.001	.002	3	6
BRCA	MPI →	+0.331	+0.039	<.001	<.001	3	6
PDAC	PCNA →	-0.357	-0.034	<.001	.006	2	6
HNSC	KNOP1 →	-0.312	-0.061	<.001	.003	3	5
BRCA	VPS39 →	+0.166	+0.034	<.001	.002	3	5
BRCA	CLASP1 →	-0.155	-0.033	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009313 vs TPP1 — OV

Explore this scatter interactively →