Oligosaccharide catabolic process

Across TCGA patient cohorts, RNA activity of the Oligosaccharide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDCA5, CKS1B, and HASPIN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligosaccharide catabolic process activity versus CDCA5 in BRCA (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDCA5 →	-1.126	-0.209	<.001	<.001	3	5
BRCA	CKS1B →	-0.829	-0.148	<.001	<.001	3	5
BRCA	HASPIN →	-0.578	-0.110	<.001	.005	3	5
BRCA	CDC25A →	-0.945	-0.218	<.001	<.001	3	4
BRCA	DDIAS →	-0.658	-0.153	.002	<.001	3	4
BRCA	CC2D2A →	+0.424	+0.148	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009313 vs CDCA5 — BRCA

Explore this scatter interactively →