Oligosaccharide catabolic process

Across TCGA cell cohorts, RNA activity of the Oligosaccharide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDF11, EPHB2, and SORBS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GDF11 grouped by Oligosaccharide catabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GDF11 →	+1.492	+1.655	.008	<.001	3	4
LARGE_INTESTINE	EPHB2 →	-2.947	-1.307	.001	.003	3	4
CNS	SORBS2 →	+1.844	+1.117	.006	.001	3	4
UPPER_AERODIGESTIVE_TRACT	TLCD5 →	+1.198	+1.161	<.001	<.001	3	4
LUNG_NSCLC_LUAD	PICK1 →	+0.686	+0.785	<.001	.001	3	4
SKIN	ALDOC →	+3.427	+1.455	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GDF11 by Oligosaccharide catabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →