Oligosaccharide catabolic process

Across TCGA cell cohorts, RNA activity of the Oligosaccharide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LBH, TINF2, and CEP152, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligosaccharide catabolic process activity versus LBH in PANCREAS (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LBH →	+3.529	+0.381	.003	.001	3	4
BLOOD_Leukemia	TINF2 →	+0.789	+1.163	.001	.001	3	3
BREAST	CEP152 →	-0.872	-1.265	.006	.004	3	3
BLOOD_Lymphoma	DRAP1 →	+1.884	+1.771	.008	.007	2	4
LARGE_INTESTINE	GGACT →	-1.528	-0.773	<.001	.005	3	3
LARGE_INTESTINE	SAXO1 →	-0.052	-0.630	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009313 vs LBH — PANCREAS

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