Pyrimidine nucleoside triphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleoside triphosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A_S1377, MCM6, and MCM7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside triphosphate metabolic process activity versus TOP2A_S1377 in PDAC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TOP2A_S1377 →	+0.636	+0.028	.003	.004	3	8
LUAD	MCM6 →	+0.727	+0.051	<.001	<.001	3	7
LUAD	MCM7 →	+0.696	+0.048	<.001	<.001	3	7
LUAD	SMC4 →	+0.416	+0.041	<.001	<.001	3	7
BRCA	ADAR →	+0.431	+0.042	<.001	<.001	3	7
BRCA	UBE2T →	+0.903	+0.042	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009147 vs TOP2A_S1377 — PDAC

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