Glucocorticoid metabolic process

Across TCGA patient cohorts, RNA activity of the Glucocorticoid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSTPIP2, EIF4B_S93, and HMCN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucocorticoid metabolic process activity versus PSTPIP2 in PDAC (Pearson r = -0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PSTPIP2 →	-0.355	-0.063	<.001	<.001	3	5
LUAD	EIF4B_S93 →	-0.511	-0.038	.003	.009	3	4
LUAD	HMCN1 →	+0.454	+0.046	<.001	.004	3	4
PDAC	HSD11B2 →	+0.602	+0.059	.009	.004	3	4
PDAC	SYNPO2_S274 →	+0.413	+0.046	<.001	<.001	3	4
PDAC	CDH1 →	+0.297	+0.057	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008211 vs PSTPIP2 — PDAC

Explore this scatter interactively →