Glucocorticoid metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Glucocorticoid metabolic process pathway differs between tumor and matched normal tissue in 13 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as COAD and THCA, show the opposite pattern, with lower activity in tumor tissue.

COAD, LIHC, and THCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	Female	II,III,IV	−0.040	<.001	10	view →
LIHC	All	III,IV	+0.053	<.001	9	view →
THCA	All	II,III,IV	−0.046	<.001	9	view →
KIRP	Male	All	−0.075	<.001	8	view →
UCEC	All	All	−0.075	<.001	6	view →
HNSC	Male	All	+0.034	.002	4	view →
BRCA	All	II,III,IV	+0.030	<.001	4	view →
READ	Female	All	−0.076	.011	2	view →
CHOL	Female	All	+0.076	<.001	2	view →
PAAD	Male	All	−0.064	.028	2	view →
LUAD	Male	All	+0.045	.002	2	view →
BLCA	All	All	−0.043	.027	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 13 lineages.

GO:0008211–COAD

Open the COAD breakdown →