Chemosensory behavior

Across TCGA patient cohorts, RNA activity of the Chemosensory behavior pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMOD3, MAN1C1, and ETV6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chemosensory behavior activity versus TMOD3 in PDAC (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TMOD3 →	-0.415	-0.628	<.001	<.001	3	4
PDAC	MAN1C1 →	-0.421	-0.515	<.001	<.001	3	3
PDAC	ETV6 →	-0.346	-0.528	.001	.005	3	3
PDAC	LINC01500 →	-0.144	-0.511	.006	.009	3	3
BRCA	RAB27A →	-0.497	-0.506	.001	.005	3	3
BRCA	ACAP1 →	-0.644	-0.498	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007635 vs TMOD3 — PDAC

Explore this scatter interactively →