Notch signaling pathway

Across TCGA patient cohorts, RNA activity of the Notch signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB16, RNU6-553P, and COMP, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Notch signaling pathway activity versus ZBTB16 in BRCA (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZBTB16 →	+1.793	+0.200	<.001	.001	3	2
BRCA	RNU6-553P →	+1.584	+0.174	.002	.009	3	2
OV	COMP →	-1.885	-0.938	.007	<.001	3	2
OV	PTGFR →	-0.772	-0.661	.001	.001	3	2
OV	TOP2A →	-1.507	-0.780	<.001	.009	3	2
OV	C16orf89 →	-1.403	-1.147	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007219 vs ZBTB16 — BRCA

Explore this scatter interactively →