Notch signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Notch signaling pathway pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 179 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Notch signaling pathway pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and LUAD, show the opposite pattern, with higher activity associated with better survival.

KIRP, HNSC, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.512	0.814	<.001	99	view →
HNSC	DFS	Tertile	III,IV	0.717	0.480	<.001	87	view →
MESO	OS	Median	All	0.267	0.502	<.001	60	view →
COAD	DFS	Quartile	All	0.542	0.749	.002	56	view →
LUAD	OS	Tertile	II,III,IV	0.802	0.642	.006	39	view →
LGG	DFS	Quartile	All	0.568	0.796	<.001	33	view →
UVM	DFS	Tertile	All	0.306	0.704	.001	33	view →
ACC	OS	Quartile	III,IV	0.147	0.587	.009	25	view →
BRCA	OS	Median	III,IV	0.901	0.780	.002	21	view →
UCS	DFS	Median	III,IV	0.589	0.274	.010	18	view →
SCLC	OS	Tertile	All	0.537	0.217	.003	18	view →
LUSC	DFS	Tertile	III,IV	0.342	0.935	.007	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0007219–KIRP (OS)

Open the KIRP breakdown →