Notch signaling pathway

Across TCGA patient cohorts, RNA activity of the Notch signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRAD_S39, SIN3A_S832, and SOD3_S195, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Notch signaling pathway activity versus RRAD_S39 in OV (Pearson r = -0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RRAD_S39 →	-0.737	-0.748	.001	<.001	3	2
OV	SIN3A_S832 →	+1.121	+1.009	.001	<.001	3	2
OV	SOD3_S195 →	-2.117	-1.038	.001	.001	3	2
OV	CAVIN2_S364 →	-1.130	-1.203	<.001	<.001	3	2
OV	DDX21_S121 →	+0.715	+0.813	<.001	<.001	3	2
OV	DES_S60 →	-0.879	-0.901	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007219 vs RRAD_S39 — OV

Explore this scatter interactively →