Male meiotic nuclear division

Across TCGA patient cohorts, RNA activity of the Male meiotic nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZSCAN29, MIR370, and MIR377, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Male meiotic nuclear division activity versus ZSCAN29 in LUAD (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ZSCAN29 →	+0.289	+0.618	.006	.003	3	3
UCEC	MIR370 →	+0.851	+0.502	.002	.001	3	3
UCEC	MIR377 →	+0.189	+0.854	.009	.001	3	3
CCRCC	SYNPR-AS1 →	+0.107	+0.540	.009	.002	3	3
LUAD	THOC5 →	+0.338	+0.505	<.001	.004	3	2
LUAD	KPTN →	+0.371	+0.543	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007140 vs ZSCAN29 — LUAD

Explore this scatter interactively →