Q-omics provides the consensus-scored MIR377 profile across patient tissues and cancer cell-line models. MIR377 expression is associated with patient survival in 7 of 34 cancer types, with the highest sampling consensus in UCS. Among the 18 cancer types available for tumor–normal comparison, MIR377 is differentially expressed in 1, with the highest sampling consensus in LUSC. Additionally, MIR377 RNA expression shows 6,021 significant gene co-expression associations, with the highest sampling consensus in LUAD. Together, these results highlight UCS, LUSC, and LUAD as cancer lineages where MIR377 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MIR377 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MIR377 survival associations across molecular data types. MIR377 RNA expression shows survival associations in the most cancer types (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MIR377 RNA expression–survival associations across cancer types. High MIR377 expression shows unfavorable associations in READ, GBM, TGCT and LGG, but favorable associations in UCS and ACC. The UCS Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .005). Together, the overview and detailed table identify UCS as the clearest survival context for MIR377 RNA expression.
This table summarizes MIR377 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for MIR377. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MIR377 shows lower tumor expression in LUSC. The LUSC box plot shows higher MIR377 RNA expression in normal versus tumor tissue (log2 FC = −0.050, t-test p = .044).
This table shows molecular features associated with MIR377 in patient tissues and cancer cell lines. In patient samples, MIR377 shows the broadest associations at the RNA and protein expression levels, with LUAD recurring as the lineage with the largest associated feature set.
