Male meiotic nuclear division

Across TCGA pan-cancer cohorts, RNA activity of the Male meiotic nuclear division pathway is associated with patient survival in 30 of 34 cancer lineages. Pathway activity is summarized from the expression of its 55 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Male meiotic nuclear division pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and LUSC, show the opposite pattern, with higher activity associated with better survival.

ACC, BLCA, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	II,III,IV	0.364	0.720	<.001	88	view →
BLCA	DFS	Tertile	All	0.508	0.673	<.001	76	view →
UCS	DFS	Median	IV	0.952	0.367	.001	62	view →
LIHC	OS	Tertile	All	0.686	0.841	<.001	54	view →
LUAD	OS	Median	All	0.754	0.862	<.001	48	view →
LUSC	OS	Median	II,III,IV	0.811	0.667	.005	41	view →
KICH	DFS	Median	All	0.668	0.930	.004	41	view →
PAAD	OS	Median	II,III,IV	0.446	0.703	.003	32	view →
SARC	OS	Tertile	All	0.367	0.748	<.001	30	view →
LGG	OS	Median	All	0.853	0.933	<.001	27	view →
COAD	DFS	Quartile	IV	0.120	0.595	<.001	18	view →
SKCM	DFS	Tertile	III,IV	0.717	0.439	.006	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

GO:0007140–ACC (OS)

Open the ACC breakdown →