"Phagocytosis, recognition"

Across TCGA patient cohorts, RNA activity of the "Phagocytosis, recognition" pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SF3B6, SRRM2_T1531, and RFC1_T506, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Phagocytosis, recognition" activity versus SF3B6 in LSCC (Pearson r = -0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SF3B6 →	-0.298	-0.089	<.001	<.001	3	8
BRCA	SRRM2_T1531 →	-0.475	-0.025	<.001	.006	3	8
LSCC	RFC1_T506 →	-0.772	-0.079	<.001	<.001	3	7
LSCC	UBR5 →	-0.209	-0.072	<.001	<.001	3	7
LSCC	SCAF4 →	-0.329	-0.061	.001	.002	3	7
LSCC	ATAD2_S342 →	-1.106	-0.075	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006910 vs SF3B6 — LSCC

Explore this scatter interactively →