"Phagocytosis, recognition"

Across TCGA pan-cancer cohorts, RNA activity of the "Phagocytosis, recognition" pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 29 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher "Phagocytosis, recognition" pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and LUAD, show the opposite pattern, with higher activity associated with better survival.

SKCM, LGG, and LUAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	II,III,IV	0.538	0.179	<.001	82	view →
LGG	DFS	Median	All	0.629	0.831	<.001	54	view →
LUAD	OS	Median	All	0.756	0.626	.001	41	view →
ACC	DFS	Quartile	All	1.000	0.561	.003	32	view →
DLBC	OS	Median	IV	1.000	0.362	.003	31	view →
LAML	DFS	Quartile	All	0.299	0.667	<.001	30	view →
STAD	DFS	Tertile	IV	0.237	0.739	.010	29	view →
BRCA	DFS	Quartile	III,IV	0.809	0.924	.009	27	view →
LUSC	DFS	Quartile	All	0.242	0.474	<.001	25	view →
KIRC	OS	Quartile	All	0.537	0.747	.005	16	view →
CESC	DFS	Tertile	II,III,IV	0.906	0.708	.009	14	view →
THCA	DFS	Median	IV	1.000	0.626	.025	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0006910–SKCM (OS)

Open the SKCM breakdown →